SPRAVATO TREATMENT
A Different Approach to Depression
For adults with treatment-resistant depression, Spravato® may offer a new path forward when traditional antidepressants haven't provided enough relief.
What is Spravato?
Spravato is an FDA approved nasal spray used alongside an oral antidepressant for adults with treatment-resistant depression. Treatments are always in clinic, monitored, and by appointment only.
What to expect during Spravato treatment.
1.
Before Treatment. You meet with your provider for evaluation and to confirm if Spravato is appropriate.
2.
During Treatment. Self-administered in the office, then relax in a private space while our team monitors you.
3.
After Treatment. Observation for at least two hours. Plan a ride home. No driving until the next day after restful sleep.
Is Spravato® Right for You?
Spravato® may be an option for adults who continue to experience symptoms of depression despite trying other antidepressant treatments.
At SHEI Wellness, we begin with a comprehensive psychiatric evaluation to better understand your history, symptoms, previous treatments, and goals. Together, we’ll determine whether Spravato® is an appropriate part of your individualized treatment plan.
Your Spravato® Treatment Schedule
01 — Induction
Weeks 1–4
Twice weekly treatment
02 — Optimization
Weeks 5–8
Once weekly treatment
03 — Maintenance
Week 9 & Beyond
Typically once weekly or every other week, based on your individual response and treatment plan.
Frequently Asked Questions About Spravato®
Spravato® (esketamine) is an FDA-approved nasal spray for adults with treatment-resistant depression. It works differently from traditional antidepressants and may be used alone or as part of an individualized treatment plan. Spravato® is administered in a certified healthcare setting under the supervision of a healthcare provider, with monitoring after each treatment.
Spravato® may be appropriate for certain adults with depression, including those who have not had an adequate response to other antidepressant treatments. At SHEI Wellness, your first step is a comprehensive psychiatric evaluation to review your symptoms, treatment history, medical history, and individual needs to determine whether Spravato® may be appropriate for you.
Spravato® is self-administered as a nasal spray under the supervision of our clinical team. After receiving your dose, you’ll relax in a comfortable treatment space while we monitor you, including your blood pressure and overall response to treatment.
You will be monitored at SHEI Wellness for at least two hours after each treatment. Before you leave, your healthcare provider will assess you to make sure you are clinically stable and ready for discharge.
Answer:
No. You will need to arrange for a responsible adult to drive you home after every Spravato® treatment. You should not drive, operate machinery, or perform activities requiring full alertness until the following day after a restful sleep.
Answer:
Many insurance plans provide coverage for Spravato® when medical-necessity requirements are met. Coverage and out-of-pocket costs vary by plan. SHEI Wellness will work with you to verify your benefits and complete any required prior authorization before treatment begins.

